Stripping Memories of Emotion

Fascinating article in Discover on a new technique for helping people with post-traumatic stress disorder. In effect, the method uses emotion-suppressing drugs to record unemotional memories over the emotionally charges ones that create so much pain:

More than a year after her accident, Magil saw Brunet’s ad for an experimental treatment for PTSD, and she volunteered. She took a low dose of a common blood-pressure drug, propranolol, that reduces activity in the amygdala, a part of the brain that processes emotions. Then she listened to a taped re-creation of her car accident. She had relived that day in her mind a thousand times. The difference this time was that the drug broke the link between her factual memory and her emotional memory. Propranolol blocks the action of adrenaline, so it prevented her from tensing up and getting anxious. By having Magil think about the accident while the drug was in her body, Brunet hoped to permanently change how she remembered the crash. It worked. She did not forget the accident but was actively able to reshape her memory of the event, stripping away the terror while leaving the facts behind.

Brunet’s experiment emerges from one of the most exciting and controversial recent findings in neuroscience: that we alter our memories just by remembering them. Karim Nader of McGill—the scientist who made this discovery—hopes it means that people with PTSD can cure themselves by editing their memories. Altering remembered thoughts might also liberate people imprisoned by anxiety, obsessive-compulsive disorder, even addiction. “There is no such thing as a pharmacological cure in psychiatry,” Brunet says. “But we may be on the verge of changing that.”

Of course if this works as well as suggested here it could be put to some strange uses, but for a moment I choose to celebrate the possibly therapeutic value.