In biomedical science, at least one thing is apparently reproducible: a steady stream of studies that show the irreproducibility of many important experiments. In a 2011 internal survey, pharmaceutical firm Bayer HealthCare of Leverkusen, Germany, was unable to validate the relevant preclinical research for almost two-thirds of 67 in-house projects. Then, in 2012, scientists at Amgen, a drug company based in Thousand Oaks, California, reported their failure to replicate 89% of the findings from 53 landmark cancer papers.If reproducing all experiments is not practical, the NIH should certainly insist that early-stage studies of new treatments be independently reproduced before proceeding to expensive clinical trials. This seems so obvious to me that I was shocked to discover it is not already NIH policy.
Friday, August 2, 2013
Replicating Medical Studies
The NIH, tired of paying for studies that are trumpeted in major journals but then can't be replicated, is considering a requirement that all grant recipients pay somebody to try to reproduce their studies before publication. I think this is a great idea. It would be expensive, but the NIH has a budget of $29 billion and I say better fewer studies that we know are right than more uncertainty. This is, after all, a huge problem:
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1 comment:
I suspect that this isn't an NIH rule because someone stands to benefit from that loophole.
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