In this interview with Kash Patel, genetist David Reich says that human genetic change was fastest between 5,000 and 2,000 years ago. Changes associated with the Bronze and Iron Ages seem to have been far more dramatic than those that took place during the agricultural revolution:
In this part of the world—Europe and the Middle East—we are actually in a period of accelerated natural selection. One way to see this is to look at the enrichment pattern we’re observing, where immune traits are unusually associated with these selection signals. We could compare the last 5,000 years of our time period, what’s called the Bronze Age and further onward, to the previous 5,000 years. What we see is that this intensification of selection around immune traits, and similarly the intensification around metabolic traits, has accelerated over this time period.One example:
It’s not like natural selection has been at the same rate over all places and times. It’s increasing over the time period we’re analyzing. Plausibly the whole time period has increased compared to previous periods. We’re in a period of intensified selection. That’s not implausible, because this is a population that went through a huge shock in terms of the way people live and the culture. Almost everyone we’re analyzing are farmers or food producers in one way or another. Farming was invented for the first time anywhere in the world in the Middle East 11,000 or 12,000 years ago. The people who invented farming exploded into Europe after 8,500 years ago, spread across the continent, and expanded rapidly.
In the Bronze Age, there was an intensification of how people lived, with much higher population densities. People were living more and more next to their animals and getting their diseases, and exchanging their diseases with the animals and with each other. This is a period of rapid change in how people are living, resulting in different biological needs of this population. It’s not surprising, perhaps, that in the context of these dramatic changes, the biology of the population might not be ideally adapted.
There might be what some people call an evolutionary mismatch, where you take a genetic variation that evolved in hunter-gatherers and put it into farmers or pastoralists, and it’s not exactly right. What you’re seeing is the DNA of this population, which descended from hunter-gatherers only 10,000 years ago, reacting to the shock of having been moved into an agricultural, Bronze Age, high-population-density, urban environment. A hypothesis is that what we’re seeing is the adaptation that occurs as a result.
One of the things we do in this work is look carefully at many of these positions in the DNA. . . . One of the things we see is that, while for the most part the signals of natural selection we detect are consistent with constant natural selection over time, in a handful of them we’re able to see that there’s been a reversal or a radical change in natural selection. Very often that occurs in the period between 5,000 to 2,000 years ago, which is the Bronze Age and the Iron Age, a period of rapid population growth and rapid movement to intensive use of many technologies that were not used that way before.
An example of this is the TYK2 genetic variant that is a major risk factor for severe tuberculosis, which is the most important infectious disease killer in the world today. If you look at this major risk factor for tuberculosis, this variant rockets up in frequency from 8,000 or 6,000 years ago to maybe 9% or 10% in this part of the world. Then it rockets down in frequency in the last 3,000 years. In both cases, there’s very clear evidence of natural selection, in the first case to increase in frequency, and in the next case to decrease in frequency.
A possible reason is the spread of tuberculosis. It maybe becomes endemic in the population 2,000 or 3,000 years ago. That’s potentially consistent with pathogen sequence data and other lines of evidence. And maybe this variant was protecting against something before then, but then tuberculosis became significant after that point, and it was so bad that it pushed in the opposite direction. That’s speculative.















































