Dr. Tu won a Lasker Award in 2011 for her discovery of Artemisinin. During the Cultural Revolution, in the 1960s, the Chinese government began a project to find a new malaria drug that could replace the standard treatment, chloroquine, which was losing effectiveness as malaria parasites developed resistance.So somebody actually did find a way to get something good out of the Cultural Revolution. I imagine the command came down from Beijing to cast aside western imperial medicine and rely on the wisdom of the people, or something like that. Youyou Tu and her colleagues took that as a call to get serious about the scientific testing of traditional remedies, with spectacular results.
Dr. Tu and her colleagues pored over the literature on ancient Chinese remedies and collected 380 extracts from 200 herbs that offered promise. One of the plants they studied was sweet wormwood, or Artemisia annua, which was used by Chinese herbalists centuries ago to treat fever. They found a way to extract an active substance from the plant, removed a toxic portion of it and show that it wiped out the malaria-causing parasite in animals. Today, Artemisinin and its derivatives are typically coupled with other therapies as the “first-line treatment” to combat malaria.
Artemisinin, when used in combination therapy, is estimated to reduce mortality from malaria by more than 20 percent over all, and by more than 30 percent in children. In Africa alone, it saves more than 100,000 lives each year.
Monday, October 5, 2015
Strange Path to a Nobel Prize
Noble Prize in medicine was Chinese doctor Youyou Tu, born 1930: